La biología sintética como desafío para comprender la autonomía de lo vivo

Autores/as

  • Sara Murillo-Sánchez Universidad del País Vasco (UPV/EHU)
  • Kepa Ruiz-Mirazo Universidad del País Vasco (UPV/EHU)

DOI:

https://doi.org/10.3989/isegoria.2016.055.08

Palabras clave:

auto-organización, autocatálisis, metabolismo, célula mínima, autonomía biológica, origen de vida, fabricación

Resumen


En este artículo se ofrece una visión de la biología sintética alternativa a los planteamientos ingenieriles que marcan gran parte de la agenda de investigación del campo. Nuestro análisis se centra en enfoques, teóricos y experimentales, cuyo objetivo fundamental es la comprensión del fenómeno de la vida per se. Una revisión detallada de varios casos de implementación artificial, in vitro, de sistemas químicos ‘auto-productivos’ nos ayudará a reflexionar sobre el enorme reto que supone transformar una disciplina científica eminentemente descriptiva, como la biología, en un proyecto que incluya y potencie líneas de investigación basadas en la idea de síntesis o fabricación. El reto es mayúsculo debido al carácter intrínsecamente metabólico de los sistemas biológicos, lo cual hace que nuestro empeño en controlarlos o en construirlos de novo sea mucho más dificultoso, forzándonos a desarrollar plataformas de intervención/implementación a nivel molecular que no pongan en compromiso esa inherente dimensión autónoma de lo vivo.

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Citas

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2016-12-30

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Murillo-Sánchez, S., & Ruiz-Mirazo, K. (2016). La biología sintética como desafío para comprender la autonomía de lo vivo. Isegoría, (55), 551–575. https://doi.org/10.3989/isegoria.2016.055.08

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